Vitamin D modulates the composition of extracellular matrix produced by smooth muscle cells and endothelial cells from human aorta

Vitamin D is involved in a wide variety of metabolic processes, including calcium homeostasis, immune modulation, hormone secretion, cell proliferation and dif- ferentiation. Hypovitaminosis D has been increasingly recognized as an inde- pendent risk factor for cardiovascular and related diseases.

Breast cancer cells damaged by chemotherapy accelerate tumor growth

Chemotherapy and radiation are basic cancer therapies aimed at reducing tumor burden. These toxic agents destroy both malignant and normal cells thereby increasing the population of dying cells and/or tumor debris and causing other changes in the tumor microenvironment. These dead cells can act as a source of stimulants on surviving tumor cells

Beneficial metabolic effects of Vitamin D on arterial wall cells in vitro

In recent years, many studies have shown positive effects of vitamin D on health, including various benefits to inflammation and immune response, cognitive function, protection against metabolic syndrome and cardiovascular disease.1 Vitamin D deficiency has been closely related to the development of coronary heart disease and its mortality.

Antitumor effect of a nutrient mixture on colon cancer cells

Colorectal cancer is the second most deadly cancer in the United States and there is an urgent need to develop effective preventive and therapeutic strategies against it. The aim of our study was to investigate the antitumor effects of a nutrient mixture containing ascorbic acid, lysine, proline and green tea extract that has been previously demonstrated a strong anticancer activity in several cancer cell types.

Different multi-nutrient formulations support calcification process in human bone cells

Bone is a specialized connective tissue and its formation involves many steps and stages. It is a dynamic tissue that responds to many internal and external factors and adapts to changing functional conditions. Bone is composed of various types of cells and collagenous extracellular organic matrix, which is predominantly type I collagen (85–95%) that becomes hardened by the deposition of […]

Vitamin D enhances anticancer effects of EGCG and a specific micronutrient combination in breast cancer cells

Breast cancer is the most common cancer in women worldwide with over 508,000 deaths due to breast cancer in 2011. Current breast cancer therapies include localized surgery and radiation, as well as systemic treatments such as chemotherapy and hormone therapy. Although newer pharmaceutical options, such as […]

Micronutrient complexes support glucose metabolism in skeletal muscle cells

As a key substrate for generating biological energy in all of the body’s cells, glucose is vital for sustaining life. Numerous other metabolic processes and bodily functions also depend on a steady supply of glucose. In all aspects, optimum intracellular transport of glucose is essential for a healthy metabolism and for maintaining healthy blood glucose levels.

Peptide vaccines directed against human Metalloproteinases (MMPs) with anti-tumor efficacy in vitro and in vivo

Despite sporadic progress, cancer has thus far eluded preventive and therapeutic approaches that can lead to an effective control of this global epidemic. The single most important reason for this failure is the fact that no effective intervention became available to impede the pathological pathways common to all types of cancer. In our study, we targeted […]

Effects of Various Multi-Nutrient Supplements on the Production and Extracellular Deposition of Collagen I and IV by Human Aortic Smooth Muscle Cells

Chronic vitamin deficiency is an underlying cause of many modern human chronic diseases, including cardiovascular disease (CVD). A major pathological mechanism leading to the development of CVD is loss of vascular-wall integrity, a structural weakness that triggers the atherosclerotic process. The arterial wall is composed of the constituent cells and surrounding […]