Peptide vaccines directed against human Metalloproteinases (MMPs) with anti-tumor efficacy in vitro and in vivo

Despite sporadic progress, cancer has thus far eluded preventive and therapeutic approaches that can lead to an effective control of this global epidemic. The single most important reason for this failure is the fact that no effective intervention became available to impede the pathological pathways common to all types of cancer. In our study, we targeted […]

Effects of Various Multi-Nutrient Supplements on the Production and Extracellular Deposition of Collagen I and IV by Human Aortic Smooth Muscle Cells

Chronic vitamin deficiency is an underlying cause of many modern human chronic diseases, including cardiovascular disease (CVD). A major pathological mechanism leading to the development of CVD is loss of vascular-wall integrity, a structural weakness that triggers the atherosclerotic process. The arterial wall is composed of the constituent cells and surrounding […]

Aluminum toxicity in Alzheimer‘s disease, breast cancer and vaccine adjuvants

We live in the age of aluminum (Al), faced with an increased exposure to this non-essential metal. While Al is ubiquitously present in the earth’s crust, it was not identified until 1808, and was only isolated in pure form in 1825. In 1886 the industrial process of smelting Al was developed (the Hall-Héroulth process), which is still the state-of-the-art technique for Al production. With the onset of World War II, Al became a key […]

Micronutrients in mitigating the adverse health effects of air pollution – part 2

Air pollution is a major environmental risk to human health and well-being. According to WHO reports in 2012, ambient (outdoor) and indoor air pollution was linked to 7 million premature deaths worldwide. Most were attributed to cardiovascular diseases (stroke and ischemic heart disease), chronic obstructive pulmonary disease (COPD), lung cancer, and acute lower respiratory infections in children. Yet, 92% of the […]